Th9 and allergic disease
نویسندگان
چکیده
منابع مشابه
Th9 cells: differentiation and disease.
CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the ...
متن کاملDriving forces of inflammatory diseases: Th9 in allergic rhinitis and estrogen in SLE.
Destructive immune-mediated diseases are often accompanied with microenvironments that drive the vicious cycles of inflammation and pathological conditions. In this issue, two reports on allergic rhinitis and SLE revealed the association of IL-9 producing helper T cells and estrogen as enhancers of allergic rhinitis (AR) and lupus, respectively. IL-9-producing helper T cell (Th9) was first thou...
متن کاملDistinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites.
Migration of Th cells to peripheral sites of inflammation is essential for execution of their effector function. The recently described Th9 subset characteristically produces IL-9 and has been implicated in both allergy and autoimmunity. Despite this, the migratory properties of Th9 cells remain enigmatic. In this study, we examined chemokine receptor usage by Th9 cells and demonstrate, in mode...
متن کاملPeripheral blood Th9 cells and eosinophil apoptosis in allergic asthma patients
Material and Methods 18 patients with allergic asthma (AA) and 14 patients with allergic rhinitis (AR) were examined. The control group included 16 healthy subjects (HS). All AA and AR patients did not take inhaled corticosteroids at least for one month and/or histamine antagonists at least for one week. Peripheral blood eosinophils and CD4+ cells were isolated by high density gradient centrifu...
متن کاملRole of Tyk-2 in Th9 and Th17 cells in allergic asthma
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. We also observed increased Th9 cells expressing IL-9 and IL-10 as well as T helper cells expressing IL-6, IL-10 and IL-2...
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ژورنال
عنوان ژورنال: Immunology
سال: 2009
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2009.03114.x